Review Article

Long-term outcomes in perinatally HIV-infected adolescents and young adults on antiretroviral therapy: a review of South African and global literature

Published in: African Journal of AIDS Research
Volume 19, issue 1, 2020 , pages: 1–12
DOI: 10.2989/16085906.2019.1676802
Author(s): Kim AndersonSchool of Public Health and Family Medicine, South Africa, Rudzani MuloiwaDepartment of Paediatrics, South Africa, Mary-Ann DaviesSchool of Public Health and Family Medicine, South Africa

Abstract

Paediatric antiretroviral programmes have been implemented globally for more than a decade, yet information on long-term treatment outcomes in perinatally HIV-infected adolescents is limited. Published literature on long-term treatment outcomes was reviewed, including virologic, immunologic and growth outcomes, as well as drug resistance and factors associated with drug resistance. Outcomes were compared between high-income countries and low- and middle-income countries (LMIC), with additional focus on South Africa, the country with the biggest HIV epidemic in the world and the largest treatment programme. Treatment outcomes varied but viral suppression results globally were generally concerning. No studies from LMIC have reported on outcomes after >10 years follow-up, demonstrating that further studies are needed.

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