Other

HPV L1 capsid protein detection in high-risk human papillomavirus-positive cervical smears

Published in: Southern African Journal of Gynaecological Oncology
Volume 6 , issue 1 , 2014 , pages: 22–26

DOI: 10.1080/20742835.2014.11441224

Author(s): N Heunis Department of Anatomical Pathology – Cytology, , A Horton Consultant Pathologist and Clinical Virologist, Department of Medical Virology, , K L Richter Consultant Pathologist and Clinical Virologist, Department of Medical Virology, , G Dreyer Department of Obstetrics and Gynaecology, , M Louw Department of Anatomical Pathology,

Keywords: HPV , L1 capsid protein , Cytoactiv® , HIV , LSIL , cervical smear , HSIL

Download full text Get new issue alerts

Abstract

Background: The L1 capsid protein is a viral nuclear protein that encapsidates the human papillomavirus (HPV) DNA to build new infectious particles. Previous studies in immune-competent patients have shown that detectable L1 protein in lowgrade squamous intraepithelial lesion (LSIL) smears is associated with remission in 60–75% of cases. Thus, the test can reduce interventions by approximately 75%.

« The role of sentinel lymph node biopsy in cervical cancer: an overview of the literature

A case study on Rosai-Dorfman disease occurring within the pelvis »