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Oropharyngeal carcinoma: a sexually transmitted disease
Item type: Journal Article • Journal: South African Family Practice • Authors: WFP Van Heerden --- Department of Oral Pathology and Oral Biology, South Africa AW Van Zyl --- Department of Periodontics and Oral Medicine, South AfricaHuman papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is on the increase and accounts for 18% to 63% of OPC. It occurs mostly in young males with no other identifiable risk factors. The vast majority of HPV-associated OPC is attributable to HPV16... -
Cervical cancer in Southern Africa: The challenges
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: M Moodley --- Department of Obstetrics and Gynaecology, -
Understanding and incorporating human papillomavirus testing in cervical cancer screening: a South African perspective
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: K L Richter --- Department of Medical Virology,The identification of human papillomavirus (HPV) as the aetiological agent for cervical cancer has important implications for the future of cervical cancer screening and prevention strategies. Despite the availability of HPV vaccines, regular and adequate screening will remain the mainstay... -
Consensus recommendations for the prevention of cervical cancer in sub-Saharan Africa
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: I F Adewole --- Department of Obstetrics and Gynaecology, Nigeria Y R Abauleth --- University Teaching Hospital of Cocody, Cote d’Ivoire I Adoubi --- Oncology Unit, Teaching Hospital of Treichville Teacher, Medical College; Coordinator of the PNLC, Cote d’Ivoire F Amorissani --- Department of Paediatrics, Cote d’Ivoire R I Anorlu --- Professor College of Medicine, University of Lagos/Lagos University Teaching Hospital, Nigeria O A Awolude --- Obstetrician and Gynaecologist College of Medicine, University of Ibadan/University College Hospital, Nigeria H Botha --- Associate Professor and Head Unit of Gynaecological Oncology, Stellenbosch University; Tygerberg Academic Hospital, South Africa J K Byamugisha --- Department of Obstetrics and Gynaecology Makerere University School of Medicine, College of Health Sciences, Makerere University, Uganda L Cisse --- Head of Neonatal Unit, Paediatric Unit, Treichville Teaching Hospital Center, Cote d’Ivoire M Diop --- Director of Dakar Cancer Institute, Le Dantec University Hospital, Senegal S Doh --- Emeritus Professor of Obstetrics and Gynaecology, Cameroon A O Fabamwo --- Lagos State University College of Medicine Ikeja, Nigeria D Gahouma --- Clinic Union Medical, University of Health Sciences, Gabon H S Galadanci --- Medical Advisory Committee; Obstetrician and Gynaecologist, Aminu Kano Teaching Hospital, Nigeria D Githanga --- Kenyan Paediatric Association, Kenya T M Magure --- University of Zimbabwe College of Health Sciences, Zimbabwe C Mabogunje --- Massey Street Children’s Hospital, Nigeria J Mbuthia --- University of Nairobi, Kenya L W Muchiri --- Department of Human Pathology, Kenya O Ndiaye --- Cheikh Anta Diop University of Dakar, A M Nyakabau --- Clinical Oncologist, Parirenyatwa Hospital, Zimbabwe S B O Ojwang --- Professor of Obstetrics and Gynaecology, University of Nairobi, Kenya D Ramogola-Masire --- University of Pennsylvannia; University of Botswana, Botswana O Sekyere --- Korle-Bu Teaching Hospital, Ghana T H Smith --- University of Witwatersrand, Charlotte Makeke Johannesburg Academic Hospital, South Africa F O G Taulo --- Director Centre for Reproductive Health, Deputy Head and Associate Professor College of Medicine, Malawi A Wewege --- Private Practice, South Africa E Wiredu --- University of Ghana Medical School and School of Allied Health Sciences, Ghana O Yarosh --- Yarosh Medservice (PTY), Gaborone Private Hospital, BotswanaCervical cancer is the second most common cancer and the leading cause of cancer-related death in women in sub-Saharan Africa. It is estimated that more than 200 million females older than 15 years are at risk in this region. This... -
Alternative sampling methods for cervical cancer screening: practical perspectives from the laboratory
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: K L Richter --- Consultant Pathologist and Clinical Virologist, Department of Medical Virology,The coverage of cervical cancer screening in South Africa is inadequate, with an estimated 8.8-million unscreened women who are mainly serviced by the public health sector in lower-resourced areas. Alternative screening options need to be considered. Every step in the... -
Human papillomavirus DNA testing on self-collected vaginal tampon samples as a cervical cancer screening test in a Gauteng population
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: E F Mnisi --- Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, G Dreyer --- Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, K L Richter --- Department of Medical Virology, University of Pretoria; Tshwane Academic Division, A Horton --- Department of Anatomical Pathology, University of Pretoria; Tshwane Academic Division, L C Snyman --- Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology,Background: There is a need to simplify cervical cancer screening to reach more women. Tampon-collected specimens can be tested using molecular methods, but this type of self-screening has not been properly evaluated as a screening method in South Africa before... -
Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: M C Van Aardt --- Head Gynaecological Oncology Unit, Steve Biko Academic Hospital, University of Pretoria, G Dreyer --- Head Gynaecological Oncology Unit, Steve Biko Academic Hospital, University of Pretoria, K L Richter --- Department of Medical Virology, P Becker --- Biostatistician, Biostatistics Unit, South African Medical Research Council, TygerbergObjectives: Knowledge of human papillomavirus (HPV) distribution in the general population is crucial for the development of new HPV vaccines and to provide a baseline from which to monitor the impact of current HPV vaccines in the future. HPV-type distribution... -
The effect of human immunodeficiency virus prevalence on the epidemiology of conventional cervical cytological abnormalities: an institutional experience
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: L C Snyman --- Department Obstetrics and Gynaecology, Kalafong Academic Hospital, G Dreyer --- Head, Gynaecological Oncology Unit Department Obstetrics and Gynaecology,Objectives: Despite a shift towards other screening modalities, cervical cytology still has an important screening function in many settings. The worldwide human immunodeficiency virus (HIV) epidemic has impacted severely on cervical cancer, resulting in women presenting at a younger age... -
HPV L1 capsid protein detection in high-risk human papillomavirus-positive cervical smears
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: N Heunis --- Department of Anatomical Pathology – Cytology, A Horton --- Consultant Pathologist and Clinical Virologist, Department of Medical Virology, K L Richter --- Consultant Pathologist and Clinical Virologist, Department of Medical Virology, G Dreyer --- Department of Obstetrics and Gynaecology, M Louw --- Department of Anatomical Pathology,Background: The L1 capsid protein is a viral nuclear protein that encapsidates the human papillomavirus (HPV) DNA to build new infectious particles. Previous studies in immune-competent patients have shown that detectable L1 protein in lowgrade squamous intraepithelial lesion (LSIL) smears... -
Anal human papillomavirus and anal squamous cell cancer in people living with HIV/AIDS: implications for southern africa
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: S Chirkut --- King Edward VIII Hospital,Southern Africa has the largest burden of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) in the world. Highly active antiretroviral therapy (HAART) is increasingly being made available in the region. The disease has shifted from being a death sentence... -
p16 and Ki-67 immunohistochemical staining reduces inter- and intra-observer variability in the grading of cervical squamous intraepithelial lesions of South African women
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: Christa Solomon --- National Health Laboratory Services (Tshwane Academic Division), Department of Anatomical Pathology, South Africa Melanie Louw --- National Health Laboratory Services (Tshwane Academic Division), Department of Anatomical Pathology, South Africa Mc van Aardt --- Department of Obstetrics and Gynaecology, South Africa Greta Dreyer --- Department of Obstetrics and Gynaecology, South AfricaBackground: Cervical carcinoma was the second leading malignancy in South African women (following breast carcinoma) in 2010. This study aimed to correlate histopathological criteria and immunohistochemical stains in terms of the grading of cervical intraepithelial precursor lesions and evaluate intra-... -
Knowledge, awareness and attitude towards human papilloma virus vaccine in a resource-constrained setting: a comparison between an urban and rural population in South Africa
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: Lwangila W Shabani --- Department of Obstetrics and Gynaecology Registrar, Greys Hospital, South Africa Manivasan Moodley --- Department of Gynaecological Oncology, South Africa Thinagrin Dhasarathun Naidoo --- Department of Obstetrics and Gynaecology, South AfricaObjectives: This study compared the knowledge, awareness and attitude towards the human papilloma virus (HPV) vaccine between urban and rural population groups. -
A retrospective study comparing the efficiency of recurrent LSIL cytology to high-grade cytology as predictors of high-grade cervical intraepithelial neoplasia or worse (CIN2+)
Item type: Journal Article • Journal: Southern African Journal of Gynaecological Oncology • Authors: R Suleman --- , South Africa MH Botha --- , South Africa