Article

Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer

Published in: Journal of Endocrinology, Metabolism and Diabetes of South Africa
Volume 13 , issue 2 , 2008 , pages: 58–63

DOI: 10.1080/22201009.2008.10872171

Author(s): Kensese Sontin Mossanda Department of Chemical Pathology, , Elizabeth Bosede Bolajoko Department of Chemical Pathology, , Mpho Moropane Department of Anatomical Pathology, , Francis Adeniyi Department of Chemical Pathology, Nigeria , Olubayo Akinosun Department of Chemical Pathology, Nigeria , Adesoji Fasanmade Department of Medicine,

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Abstract

Objective. Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer subjects were assessed and compared with apparently healthy normal subjects to understand the involvement of OS in the subjects.

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