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Antimicrobial Susceptibility Patterns of Selected Bacteraemic Isolates from South African Public Sector Hospitals, 2010

Published in: Southern African Journal of Epidemiology and Infection
Volume 26 , issue 4 , 2011 , pages: 243–250

DOI: 10.1080/10158782.2011.11441461

Author(s): C Bamford National Health Laboratory Service (NHLS), Groote Schuur and University of Cape Town, , K Bonorchis National Health Laboratory Service (NHLS), Green Point and University of Cape Town, , A Ryan National Health Laboratory Service (NHLS), Green Point and University of Cape Town, , J Simpson National Health Laboratory Service (NHLS), Green Point and University of Cape Town, , E Elliott National Health Laboratory Service (NHLS), Universitas and University of the Free State, , R Hoffmann National Health Laboratory Service (NHLS), Tygerberg and Stellenbosch University, , P Naicker National Health Laboratory Service (NHLS), Tygerberg and Stellenbosch University, , N Ismail National Health Laboratory Service (NHLS), Steve Biko Academic and University of Pretoria, , N Mbelle National Health Laboratory Service (NHLS), Dr George Mukhari and University of Limpopo, , M Nchabeleng National Health Laboratory Service (NHLS), Dr George Mukhari and University of Limpopo, , T Nana National Health Laboratory Service (NHLS), Charlotte Maxeke Johannesburg Academic and University of the Witwatersrand, , C Sriruttan National Health Laboratory Service (NHLS), Charlotte Maxeke Johannesburg Academic and University of the Witwatersrand, , S Seetharam National Health Laboratory Service (NHLS), Chris Hani Baragwanath and University of the Witwatersrand, , J Wadula National Health Laboratory Service (NHLS), Chris Hani Baragwanath and University of the Witwatersrand,

Keywords: surveillance , antimicrobial resistance , bacteraemia , carbapenem resistance , South Africa , public sector

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Abstract

We report on antimicrobial susceptibility surveillance data for six key bloodstream pathogens (Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus) identified in public sector hospitals in South Africa during 2010. Major findings include the accelerated emergence of carbapenem resistance among K. pneumoniae and Enterobacter species, with overall susceptibility rates of 98% and 96% for ertapenem, and above 99% for meropenem and imipenem. Levels of resistance among P. aeruginosa and A. baumannii remain high in all centres, with few changes since 2009. Large decreases in piperacillin-tazobactam susceptibility rates were noted at three institutions, probably related to methodological issues. S. aureus remains a major pathogen countrywide, with between 30-60% of isolates resistant to cloxacillin [methicillin-resistant S. aureus (MRSA)]. Ongoing surveillance for antimicrobial resistance is vital, and the use of a centralised data extraction system may aid in this.

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