Ectopic ACTH syndrome: a clinical challenge

Abstract

A patient was managed in our endocrinology unit with ectopic Cushing's syndrome from an adrenocorticotropic hormone-producing neuroendocrine carcinoma of the anal canal. There was limited response to standard therapy, which made it difficult to correct the electrolyte and metabolic derangements associated with the disease. This is a summary of the challenges encountered during treatment.