Search
Search results for
We found
6 results for you
-
Safety of pain control with morphine: new (and old) aspects of morphine pharmacokinetics and pharmacodynamics
Item type: Journal Article • Journal: Southern African Journal of Anaesthesia and Analgesia • Authors: JF Coetzee --- Department of Anesthesiology and Critical Care,Background: A 26-year-old, 59 kg female was administered morphine 10 mg during tonsillectomy, and 5 mg in the recovery room. She died 5 hours after the operation. Hypoxic cerebral injury, arising from morphine side-effects, was pronounced the cause of death,... -
Strategies for the Prevention and Containment of Antibiotic Resistance
Item type: Journal Article • Journal: South African Family Practice • Authors: SY Essack --- School of Pharmacy and Pharmacology, University of Kwazulu-Natal,Antibiotic resistance may emerge by antibiotic selection pressure but is perpetuated by diverse risk factors and maintained within environments as a result of poor infection control. Population-specific drug pharmacokinetics and pharmacodynamics also play a role. The WHO, US, UK and... -
A pilot study on the use of amikacin in neonates: Who should be monitored for ototoxicity?
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Deirdré Engler --- Department of Pharmacy, South Africa Natalie Schellack --- Department of Pharmacy, South Africa Alida Naude --- Discipline of Speech- Language Pathology and Audiology, South Africa Andries Gous --- Department of Pharmacy, South AfricaBackground: Aminoglycosides (AGs) cause irreversible hearing loss. The toxic effects of AGs are dose dependent and correlate with increasing drug serum concentrations. -
A multi-centre, phase IV study to evaluate the steady-state plasma concentration and serum bactericidal activity of a generic teicoplanin preparation
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Oppel Greeff --- Department of Pharmacology, School of Medicine, Faculty of Health Sciences, South Africa Jacob van Tonder --- Department of Pharmacology, School of Medicine, Faculty of Health Sciences, South Africa Duncan Cromarty --- Department of Pharmacology, School of Medicine, Faculty of Health Sciences, South Africa Warren Lowman --- Department of Clinical Microbiology and Infectious Diseases, School of Pathology, South Africa Piet Becker --- Faculty of Health Sciences, South Africa Margo Nell --- Department of Pharmacology, School of Medicine, Faculty of Health Sciences, South AfricaIntroduction: Teicoplanin is an effective treatment option against methicillin-resistant, Gram-positive bacteria, like Staphylococcus aureus. It is a glycopeptide antibiotic, produced through microbial fermentation, a process resulting in variations in the N-acyl side chain. Concerns that these variations may affect the... -
A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies
Item type: Journal Article • Journal: Journal of Endocrinology, Metabolism and Diabetes of South Africa • Authors: Oppel BW Greeff --- Department of Pharmacology, South Africa Jacob John van Tonder --- Triclinium Clinical Development (Pty) Ltd, South Africa Kershlin Naidu --- Department of Internal Medicine, South Africa Alicia McMaster --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Alet van Tonder --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Rashem Mothilal --- Sanofi-Aventis South Africa (Pty) Ltd, South AfricaGlucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily available... -
A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part two: Insulin degludec vs. insulin glargine U300
Item type: Journal Article • Journal: Journal of Endocrinology, Metabolism and Diabetes of South Africa • Authors: Oppel Bw Greeff --- Department of Pharmacology, South Africa Jacob John van Tonder --- Triclinium Clinical Development (Pty) Ltd, South Africa Kershlin Naidu --- Department of Internal Medicine, South Africa Alicia McMaster --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Alet van Tonder --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Rashem Mothilal --- Sanofi-Aventis South Africa (Pty) Ltd, South AfricaGlucose clamp studies form an integral part of the early development of insulin therapies. Data generated in these studies are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the agents, but methodological differences confound comparison of results from...