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  1. Safety of pain control with morphine: new (and old) aspects of morphine pharmacokinetics and pharmacodynamics

    Safety of pain control with morphine: new (and old) aspects of morphine pharmacokinetics and pharmacodynamics

    Item type: Journal Article • Journal: Southern African Journal of Anaesthesia and Analgesia • Authors: JF Coetzee --- Department of Anesthesiology and Critical Care,
    Background: A 26-year-old, 59 kg female was administered morphine 10 mg during tonsillectomy, and 5 mg in the recovery room. She died 5 hours after the operation. Hypoxic cerebral injury, arising from morphine side-effects, was pronounced the cause of death,...
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  2. Strategies for the Prevention and Containment of Antibiotic Resistance

    Strategies for the Prevention and Containment of Antibiotic Resistance

    Item type: Journal Article • Journal: South African Family Practice • Authors: SY Essack --- School of Pharmacy and Pharmacology, University of Kwazulu-Natal,
    Antibiotic resistance may emerge by antibiotic selection pressure but is perpetuated by diverse risk factors and maintained within environments as a result of poor infection control. Population-specific drug pharmacokinetics and pharmacodynamics also play a role. The WHO, US, UK and...
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  3. A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part two: Insulin degludec vs. insulin glargine U300

    A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part two: Insulin degludec vs. insulin glargine U300

    Item type: Journal Article • Journal: Journal of Endocrinology, Metabolism and Diabetes of South Africa • Authors: Oppel Bw Greeff --- Department of Pharmacology, South Africa Jacob John van Tonder --- Triclinium Clinical Development (Pty) Ltd, South Africa Kershlin Naidu --- Department of Internal Medicine, South Africa Alicia McMaster --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Alet van Tonder --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa Rashem Mothilal --- Sanofi-Aventis South Africa (Pty) Ltd, South Africa
    Glucose clamp studies form an integral part of the early development of insulin therapies. Data generated in these studies are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the agents, but methodological differences confound comparison of results from...
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