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A medical audit of the management of cryptococcal meningitis in HIV-positive patients in the Cape Winelands (East) district, Western Cape
Item type: Journal Article • Journal: South African Family Practice • Authors: KB Von Pressentin --- Langeberg Sub-District, Cape Winelands District, HH Conradie --- Division of Family Medicine and Primary Care, Faculty of Medicine and Health Sciences, R Mash --- Division of Family Medicine and Primary Care, Faculty of Medicine and Health Sciences,Background: Cryptococcal meningitis (CM) has become the most common type of community-acquired meningitis. CM has a poor outcome if the initial in-hospital treatment does not adhere to standard guidelines. The aim of this audit was to improve the quality of... -
Profile and acute mortality outcome of patients admitted with cryptococcal meningitis to an urban district hospital in KwaZulu-Natal, South Africa
Item type: Journal Article • Journal: South African Family Practice • Authors: BO Adeyemi --- Department of Family Medicine, South Africa A Ross --- Department of Family Medicine, South AfricaBackground: Cryptococcal meningitis (CCM) is one of the leading causes of early mortality in human immunodeficiency virus (HIV)-infected patients. This study was part of a clinical audit aimed at improving care for patients with CCM at an urban district hospital... -
Guidelines for the management of acute meningitis in children and adults in South Africa
Item type: Journal Article • Journal: Southern African Journal of Epidemiology and Infection • Authors: T.H. Boyles --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, C. Bamford --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, K. Bateman --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, L. Blumberg --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, A. Dramowski --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, A. Karstaedt --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, S. Korsman --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, D.M. le Roux --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, G. Maartens --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, S. Madhi --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, R. Naidoo --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, J. Nuttall --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, G. Reubenson --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, J. Taljaard --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, J. Thomas --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, G. van Zyl --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, A. von Gottberg --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, A. Whitelaw --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa, M. Mendelson --- Federation of Infectious Diseases Societies of Southern Africa Working Group on Acute Meningitis in Children and Adults Infectious Diseases Society of Southern Africa,This guideline provides a rational and cost-effective approach to patients with acute meningitis, which causes considerable morbidity and mortality, predominantly in children.There are many aetiologies, but a small number of bacteria and viruses account for the majority of cases. There... -
Early onset meningococcal meningitis
Item type: Journal Article • Journal: Southern African Journal of Epidemiology and Infection • Authors: Marelize Bosman --- Department Paediatrics and Child Health, Moherndran Archary --- Department Paediatrics and Child Health, Prasha Mahabeer --- Department of Clinical Microbiology, Durban Raziya Bobat --- Head of Paediatric Infectious Diseases, Nelson R Mandela School of Medicine, University of KwaZulu-Natal,Neisseria meningitidis is a rare cause of meningitis and septicaemia in the neonatal population. Meningococcal septicaemia in neonates is divided into early-onset infection (symptoms within seven days of life) and late-onset infection (8-30 days of life). Early-onset meningococcal infection is... -
Molecular detection and characterisation of mumps virus in cerebrospinal fluid in a Gauteng laboratory
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Marieke Brauer --- Faculty of Health Sciences, Department of Medical Virology, South Africa Marianne Wolfaardt --- Faculty of Health Sciences, Department of Medical Virology, South Africa Lynne M Webber --- Faculty of Health Sciences, Department of Medical Virology, South Africa Maureen B Taylor --- Faculty of Health Sciences, Department of Medical Virology, South AfricaThe study aimed to determine the presence of mumps virus (MuV) in cerebrospinal fluid (CSF) specimens and to genetically characterise detected MuV strains. A real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the MuV F gene, and characterisation... -
Recommendations for the use of meningococcal vaccines in South Africa
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Susan Meiring --- Division of Public Health Surveillance and Response, South Africa Gregory Hussey --- Vaccines for Africa Initiative, Institute for Infectious Diseases and Molecular Medicine, South Africa Prakash Jeena --- Department of Paediatrics, South Africa Salim Parker --- General Practitioner, South African Society of Travel Medicine, South Africa Anne von Gottberg --- Centre for Respiratory Diseases and Meningitis, South AfricaBackground: Although meningococcal disease (MD) incidence in South Africa is low, Neisseria meningitidis (NM) causes severe disease that is often life-threatening and can cause long-term disabilities. A quadrivalent protein-conjugated meningococcal vaccine (MCV4) is available, and provides protection against 75% of... -
Diagnostic and mortality outcomes in a cohort of adult meningitis suspects in KwaZulu-Natal
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Onke Nonkala --- Department of Internal Medicine, South Africa Colleen Aldous --- School of Clinical Medicine, South Africa Douglas Wilson --- Department of Internal Medicine, South AfricaBackground: The clinical value of lumbar puncture (LP) in settings with a high human immunodeficiency virus (HIV) prevalence has not been well defined. -
The impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitis
Item type: Journal Article • Journal: Southern African Journal of Infectious Diseases • Authors: Irma Kruger --- Department of Paediatrics and Child Health, South Africa Jean Maritz --- PathCare Reference Laboratory, South Africa Heather Finlayson --- Department of Paediatrics and Child Health, South AfricaBackground: Viral meningitis is the most common form of aseptic meningitis and requires minimal investigation and treatment. Polymerase chain reaction (PCR) has become the ‘gold standard’ for identifying viruses in cerebrospinal fluid and can provide rapid results. The objective of... -
A review of the management and outcome of patients admitted with cryptococcal meningitis at a regional hospital in KwaZulu-Natal province
Item type: Journal Article • Journal: South African Family Practice • Authors: Andrew J Ross --- Department of Family Medicine, South Africa Egide Ndayishimiye --- Prince Mshiyeni Memorial Hospital, Master of Public Health (MPH), South AfricaBackground: South Africa has 7.06 million people who are HIV-positive, with those having a low CD4 count being susceptible to cryptococcal meningitis (CCM), which has an estimated mortality of 30–50%. This study aimed to establish the outcome of patients admitted...