Article

Horizontal transfer of OXA-23-carbapenemase-producing Acinetobacter species in intensive care units at an academic complex hospital, Durban, KwaZulu-Natal, South Africa

Published in: Southern African Journal of Infectious Diseases
Volume 32 , issue 4 , 2017 , pages: 119–126

DOI: 10.1080/23120053.2017.1335482

Author(s): Khine Swe Swe-Han Department of Medical Microbiology, South Africa , Melendhran Pillay Department of Medical Microbiology, South Africa , Desmond Schnugh Infection Control Services Laboratory, Department of Clinical Microbiology and Infectious Diseases, South Africa , Koleka P Mlisana Department of Medical Microbiology, South Africa , Kamaldeen Baba Department of Medical Microbiology, National Health Laboratory Service, South Africa , Manormoney Pillay Medical Microbiology and Infection Control, School of Laboratory Medicine & Medical Science, South Africa

Keywords: bla_OXA-23 genes , carbapenem-hydrolysing class D β -lactamases (CHDLs) , horizontal transmission , molecular surveillance

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Abstract

Introduction: Carbapenemase production is an important mechanism of carbapenem resistance in Acinetobacter species. This study investigated the presence of the carbapenem-hydrolysing class D β–lactamase- encoding genes, bla_OXA-23 and bla_OXA-58, and their association with the spread of multidrug-resistant (MDR) Acinetobacter species in intensive care units at an academic hospital.

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