Brief Report

Factors associated with retreatment tuberculosis in Tshwane, south africa: the role of tobacco smoking

Published in: Southern African Journal of Infectious Diseases
Volume 29 , issue 2 , 2014 , pages: 87–90

DOI: 10.1080/23120053.2014.11441576

Author(s): G M C Louwagie Public Health Medicine, School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, , O A Ayo-Yusuf Dean/Director’s Office, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus Director, Southern Africa Resilient Africa Innovation Laboratory, Grant Recipient American Cancer Society,

Keywords: tobacco smoking , recurrent tuberculosis , human immunodeficiency virus , tuberculosis relapse , retreatment tuberculosis

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Abstract

There is evidence from international studies that tobacco smoking increases the risk of tuberculosis recurrence through its effects on the immunological and barrier functions of the airways. In this cross-sectional study, the association between current tobacco smoking and retreatment tuberculosis was studied in a population of 1 926 South African tuberculosis patients with high human immunodeficiency virus (HIV) co-infection rates. Retreatment tuberculosis was more common in male and among HIV-positive participants currently on antiretroviral treatment, or with unknown antiretroviral treatment status. However, we did not find an association between smoking and retreatment tuberculosis. A longitudinal study is needed to confirm these findings

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