Article

Effect of ondansetron on the analgesic efficacy of tramadol used for postoperative analgesia: a randomised controlled study

Published in: Southern African Journal of Anaesthesia and Analgesia
Volume 21 , issue 5 , 2015 , pages: 135–139

DOI: 10.1080/22201181.2015.1075935

Author(s): Archana Murmu Department of Anaesthesiology, India , Sudeshna Bhar Kundu Department of Anaesthesiology, India , Amita Pahari Department of Anaesthesiology, India , Anisha De Department of Anaesthesiology, India , Dhiman Adhikari Department of Anaesthesiology, India , Suchismita Pal Department of Anaesthesiology, India , Abhimanyu Bhattacharya Department of Anaesthesiology, India , Chiranjib Bhattacharyya Department of Anaesthesiology, India

Keywords: ondansetron , pain , postoperative nausea and vomiting , sedation , tramadol

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Abstract

Background: Ondansetron is used to reduce tramadol induced postoperative nausea and vomiting (PONV). Studies on patient-controlled analgesia (PCA) found that ondansetron reduces the analgesic efficacy of tramadol. Drug requirement in PCA and in conventional intravenous analgesia without PCA device may differ. This study evaluated the effect of ondansetron on analgesic efficacy of tramadol for postoperative analgesia without a PCA device.

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