Review

What is the link between vitamin D and tuberculosis?

DOI: 10.1080/10158782.2013.11441549
Author(s): D. KibirigeDepartment of Medicine, Uganda, D.S. KiggunduDepartment of Medicine, Uganda, W. WorodriaDepartment of Medicine, Uganda

Abstract

Tuberculosis is one of the leading causes of morbidity and mortality globally. Vitamin D directly influences the body’s immunological response to tuberculosis by modulating the production of certain antimicrobial peptides and the release of cytokines. Vitamin D deficiency has been extensively described in patients with tuberculosis. Currently, it is a recognised risk factor for tuberculosis. Genetic polymorphisms of the vitamin D receptor may influence host susceptibility to tuberculosis and response to antituberculosis therapy. This review article explores the close association between tuberculosis and vitamin D, with the aim of forming a strong basis for further interventional and genetic studies on patients with active tuberculosis.

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